Structure and function in natural product biosynthesis

Our group uses an interdisciplinary approach to understand the mechanisms of natural product biosynthetic machinery. Nonribosomal peptide biosynthetic enzymes are responsible for the production of therapeutically-important antibiotics and antitumor compounds. The study of these systems exploits our group’s skills in synthetic organic chemistry, protein crystallography and mechanistic enzymology.  A detailed understanding of biosynthetic machinery can be applied to the rational engineering of biologically useful molecules.