Bruner Lab Publications


Mousa JJ, Yang Y, Tomkovich S, Shima, A, Newsome RC, Tripathi, P, Oswald E, Bruner SD, Jobin C. MATE transport of the E. coli-derived genotoxin colibactin Nature Microbiol. 2016; 1, Article number: 15009 . doi:10.1038/nmicrobiol.2015.9. LINK


Zuo R, Zhang Y, Huguet-Tapia JC, Mehta M, Dedic E, Bruner SD, Loria R, Ding Y. An artificial self-sufficient cytochrome P450 directly nitrates fluorinated tryptophan analogs with a different regio-selectivity Biotechnol J. 2016; doi: 10.1002/biot.201500416. LINK

Li K, Li G, Bradbury LM, Hanson AD, Bruner SD.
Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli. Biochem J
. 2016, ;473(3):277-284. doi: 10.1042/BJ20150980. LINK


Li K, Bruner SD. Structure and functional analysis of the siderophore periplasmic binding protein from the fuscachelin gene cluster of Thermobifida fusca. Proteins. 2016; 84(1):118-28. doi: 10.1002/prot.24959. LINK


Di Russo NV, Condurso HL, Li K, Bruner SD, Roitberg AE. Oxygen diffusion pathways in a cofactor-independent dioxygenase. Chem Sci. 2015, 6(11):6341-6348. LINK


Li K, Chen WH, Bruner SD. Structure and Mechanism of the Siderophore-Interacting Protein from the Fuscachelin Gene Cluster of Thermobifida fusca. Biochemistry .2015 54 (25): 3989-4000. doi: 10.1021/acs.biochem.5b00354. LINK

Di Russo, NV, Bruner, SD, Roitberg, AE. Applicability of a fluorescence-based sensors to the determination of kinetic parameters for O2 in oxygenases. Anal. Biochem. 2015, 475:53-55. doi: 10.1016/j.ab.2015.01.009. LINK

Luo Z, Li Y, Mousa J, Bruner SD, Zhang Y, Pei Y, Keyhani NO. Bbmsn2 acts as a pH-dependent negative regulator of secondary metabolite production in the entomopathogenic fungus Beauveria bassiana. Environ Microbiol. 2015,4:1189-202. doi:10.1111/1462-2920 LINK


Condurso HL, Bruner SD. Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery. Nat Prod Rep. 2012, 29(10):1099-110. LINK


Dimise EJ, Condurso HL, Stoker GE, Bruner SD. Synthesis and structure confirmation of fuscachelins A and B, structurally unique natural product siderophores from Thermobifida fusca. Org Biomol Chem. 2012, 10(28):5353-6. LINK


Condurso HL, Bruner SD. Structure guided approaches toward exploiting and manipulating nonribosomal peptide and polyketide biosynthetic pathways. Curr Opin Chem Biol. 2012,16(1-2), 162-9. LINK


Liu Y, Zheng T, Bruner SD. Structural basis for phosphopantetheinyl carrier domain interactions in the terminal module of nonribosomal peptide synthetases. Chem Biol. 2011, 18(11), 1482-8. LINK


Bruner SD. Enzyme catalysis: C-H activation is a Reiske business. Nat Chem. 2011 3(5), 342-3. LINK


Cooke HA, Bruner SD. Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites. Biopolymers. 2010, 93(9), 802-10. LINK


Dimise EJ, Bruner SD. Biosynthesis: unmasking morphine. Nat Chem Biol. 2010, 6(4), 251-2. LINK


Cooke HA, Guenther EL, Luo Y, Shen B, Bruner SD. Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Biochemistry. 2009, 48(40), 9590-8. LINK


Cooke HA, Christianson CV, Bruner SD. Structure and chemistry of 4-methylideneimidazole-5-one containing enzymes. Curr Opin Chem Biol. 2009, 13(4), 460-8. LINK


Widboom PF, Bruner SD. Complex oxidation chemistry in the biosynthetic pathways to vancomycin/teicoplanin antibiotics. Chembiochem. 2009, 10(11), 1757-64. LINK


Dimise EJ, Widboom PF, Bruner SD. Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca. Proc Natl Acad Sci, 2008, 105(40), 15311-6. LINK


Luo Y, Lin S, Zhang J, Cooke HA, Bruner SD, Shen B. Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. J Biol Chem. 2008, 283(21), 14694-702. LINK


Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD. Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM. Bioorg Med Chem Lett. 2008,18(10), 3099-102. LINK


Christianson CV, Montavon TJ, Festin GM, Cooke HA, Shen B, Bruner SD. The mechanism of MIO-based aminomutases in beta-amino acid biosynthesis. J Am Chem Soc. 2007, 129(51), 15744-5. LINK


Fielding EN, Widboom PF, Bruner SD. Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC. Biochemistry. 2007, 46(49), 13994-4000. LINK


Cooke HA, Zhang J, Griffin MA, Nonaka K, Van Lanen SG, Shen B, Bruner SD. Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. J Am Chem Soc. 2007, 129(25), 7728-9. LINK


Christianson CV, Montavon TJ, Van Lanen SG, Shen B, Bruner SD. The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway. Biochemistry. 2007, 46(24), 7205-14. LINK


Widboom PF, Fielding EN, Liu Y, Bruner SD. Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis. Nature. 2007, 447(7142), 342-5. LINK


Liu Y, Bruner SD. Rational manipulation of carrier-domain geometry in nonribosomal peptide synthetases. Chembiochem. 2007, 8(6), 617-21. LINK


Undergraduate, Graduate, and Post-doctoral Work


Yeh E, Kohli RM, Bruner SD, Walsh CT. Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated. Chembiochem. 2004, 5(9), 1290-3. LINK


Tseng CC, Vaillancourt FH, Bruner SD, Walsh CT. DpgC is a metal- and cofactor-free 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase in the vancomycin biosynthetic pathway. Chem Biol. 2004, 11(9), 1195-203. LINK


Fromme JC, Bruner SD, Yang W, Karplus M, Verdine GL. Product-assisted catalysis in base-excision DNA repair. Nat Struct Biol. 2003, 10(3), 204-11. LINK


Tseng CC, Bruner SD, Kohli RM, Marahiel MA, Walsh CT, Sieber SA. Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase. Biochemistry. 2002, 41(45), 13350-9. LINK


Bruner SD, Weber T, Kohli RM, Schwarzer D, Marahiel MA, Walsh CT, Stubbs MT. Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. Structure. 2002, 10(3), 301-10. LINK


Norman DP, Bruner SD, Verdine GL. Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein. J Am Chem Soc. 2001, 123(2), 359-60. LINK


Sekino Y, Bruner SD, Verdine GL. Selective inhibition of herpes simplex virus type-1 uracil-DNA glycosylase by designed substrate analogs. J Biol Chem. 2000, 275(47), 36506-8. LINK


Bruner SD, Norman DP, Verdine GL. Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature. 2000, 403(6772), 859-66. LINK


Bruner SD, Norman DP, Fromme JC, Verdine GL. Structural and mechanistic studies on repair of 8-oxoguanine in mammalian cells. Cold Spring Harb Symp Quant Biol. 2000, 65, 103-11. LINK


Bruner SD, Nash HM, Lane WS, Verdine GL. Repair of oxidatively damaged guanine in Saccharomyces cerevisiae by an alternative pathway. Curr Biol., 1998, 8(7), 393-403. LINK


Radeke HS, Digits CA, Bruner SD, Snapper ML. New Tools for Studying Vesicular-Mediated Protein Trafficking: Synthesis and Evaluation of Ilimaquinone Analogs in a Non-Radioisotope-Based Antisecretory Assay. J Org Chem. 1997, 62(9), 2823-2831. LINK


Verdine GL, Bruner SD. How do DNA repair proteins locate damaged bases in the genome? Chem Biol. 1997, 4(5), 329-34. LINK


Nash HM, Bruner SD, Schärer OD, Kawate T, Addona TA, Spooner E, Lane WS, Verdine GL. Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol. 1996, 6(8), 968-80. LINK

Bruner, SD, Radeke, HS, Tallarico, JA, Snapper, ML. Total Synthesis of (-)-Ilimaquinone. J. Org. Chem. 1995, 60(5), 1114–1115. LINK